P-212: Ala 307 Thr Polymorphism of FSHR in Iranian Patients with Polycystic Ovary Syndrome (PCOS)
نویسندگان
چکیده مقاله:
Background: Follicle stimulating hormone (FSH) receptor plays an important role in FSH signaling during reproductive development. Any changes in FSHR gene is resulted in alteration of amino acid in protein chain, consequence to affect the binding affinity, intracellular signaling and expression levels of FSHR. FSHR polymorphisms can be involved in etiology of many reproductive disorders such as polycystic ovary syndrome. We aimed to investigate the association of rs6165 polymorphism (Thr307Ala) which can influence the FSH receptor binding affinity to FSH, with Iranian PCOS patients and correlation with drug (exogenous FSH) response. Materials and Methods: A case control study including 90 individuals (30 fertile controls, 30 control 1 and 30 PCOS patients) was performed to investigate the association of SNP rs6165 with drug response in PCO patients. The control group 1 (patients with male factor infertility) and PCO patients were candidates for Intra Uterine Insemination. Polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) method was implemented on the DNA isolated from blood samples to genotype this SNP. Results: There was significant difference between the percentage of individuals carrying this polymorphism in patients (70%) and control groups (23%). PCO patients with this SNP were shown more response to ovulation induction. Conclusion: There is association between PCOS and rs6165 polymorphism. Further studies are needed to clarify the mechanism of action of this polymorphism. Although, it seems the change of amino acid at position 307 consequences to increase the sensitivity of FSH receptor, which can be considered in ovulation induction of patients to avoid of activeness of OHSS.
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عنوان ژورنال
دوره 7 شماره 3
صفحات 119- 119
تاریخ انتشار 2013-09-01
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